Validation of Quantitative Structure-Activity Relationship (QSAR) Model for Photosensitizer Activity Prediction
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چکیده
منابع مشابه
Validation of Quantitative Structure-Activity Relationship (QSAR) Model for Photosensitizer Activity Prediction
Photodynamic therapy is a relatively new treatment method for cancer which utilizes a combination of oxygen, a photosensitizer and light to generate reactive singlet oxygen that eradicates tumors via direct cell-killing, vasculature damage and engagement of the immune system. Most of photosensitizers that are in clinical and pre-clinical assessments, or those that are already approved for clini...
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Cardiac glycosides are group of natural products found to be effective against various cancers. The aim of this study is to propose a binding mode for different conformation of cardiac glycoside analogues to Na, K ATPase pump which is an important target for various cancer cell lines. Quantitative structure activity relationships model were developed with the cytotoxic activity (Expt. IC50) of ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2011
ISSN: 1422-0067
DOI: 10.3390/ijms12128626